ToxStrategies scientists have published a new mini review on the mode of action (MOA) for gastrointestinal cancers in rodents exposed to hexavalent chromium [Cr(VI)] in drinking water, in Mutation Research. This new article is an application of ten factors previously identified as important for determining whether an agent induces a tumor through a mutagenic or non-mutagenic MOA. The review focuses on in vivo research in target tissues of target species. The article concludes that Cr(VI) is unlikely to act via a direct mutagenic mode of action in the gastrointestinal tissues that developed tumors following exposure to very high concentrations of Cr(VI). It is anticipated that other regulators will find this useful in future safety assessments of Cr(VI).
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