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ToxStrategies Scientists Publish Mini Review on MOA for CrVI in Drinking Water


ToxStrategies scientists have published a new mini review on the mode of action (MOA) for gastrointestinal cancers in rodents exposed to hexavalent chromium [Cr(VI)] in drinking water, in Mutation Research. This new article is an application of ten factors previously identified as important for determining whether an agent induces a tumor through a mutagenic or non-mutagenic MOA. The review focuses on in vivo research in target tissues of target species. The article concludes that Cr(VI) is unlikely to act via a direct mutagenic mode of action in the gastrointestinal tissues that developed tumors following exposure to very high concentrations of Cr(VI). It is anticipated that other regulators will find this useful in future safety assessments of Cr(VI).

The article is freely available and can be downloaded here. For more information about our capabilities in the field of risk assessment, literature review (including systematic review) and other services, please click here.

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