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21CT Scientists Present Talks at Summer Toxicology Forum

The Center of Excellence in 21st Century Toxicology (21CT; a division of ToxStrategies) was well represented at the 44th annual summer meeting of The Toxicology Forum (TFF), held July 9–11 in Baltimore. Dr. Susan Borghoff, 21CT Director, served on the Organizing Committee, and also participated in the session titled, “Integration of Toxicokinetics and the Kinetically-Derived Maximum Dose into Toxicity Testing and Risk Assessment.” Dr. Borghoff’s presentation was, “Kinetically Derived Maximum Dose: A Key Initiating Event Impacting Need for Mode-of-Action Investigations of High-Dose-Specific Toxicity.”

21CT toxicologists Drs. Rebecca Clewell and Miyoung Yoon were also active in the ToxForum meeting. Dr. Clewell served as a co-moderator of the session on, “Use of Alternative Liver Models for Hepatotoxicity and Disease Progression—The Future of Practical Applications for Evaluating Compound Efficacy and Toxicity” and helped facilitate the panel discussion at the end that included all presenters and other interested parties. Drs. Clewell and Yoon were co-authors of a presentation titled, “Biokinetic Modeling and IVIVE to Interpret the Results from Advanced In Vitro Liver Models for Safety and Efficacy Testing.”

In another session—“Adverse Effects as the Basis for Regulatory Decisions: What is Adverse?”—Dr. Clewell offered insights from throughout her career in a talk titled, “Moving Toward 21st Century Risk Assessment: Can We Define Adversity In Vitro?”