Publications

Doepker C, Franzen A, Brorby G, Brown L, Choksi N, East A, Wikoff D. 2026. Smoke flavoring—A case study demonstrating the value of using benefit-risk analysis for foods (BRAFO) to provide transparency for risk management decisions. Regul Toxicol Pharmacol 167(May):106033; doi: 10.1016/j.yrtph.2026.106033. PMID: 41577161.

Buerger AN, Thompson CM, Heintz MM, Maberti S, Palermo CM, Haws LC. 2026. Application of quantitative and qualitative uncertainty assessment risk management decision-making: A case study with diisononyl phthalate. Food Chem Toxicol 116110; doi: 10.1016/j.fct.2026116110. Online ahead of print April 24. PMID: 42035978.

Doepker C, Franzen A, Brorby G*, Wikoff D, Thompson C. From alerts to evidence: Advancing the use of in vivo genotoxicity dose-response data for complex mixtures. Poster/Abstract PA3, International Conference on the Science of Botanicals (ICSB), Oxford, MS, April 2026. (*poster only)

Buerger AN, Vincent MJ, Fitch S, Rivera B, Engel N, Zhang J, Rushton EK, Borghoff SJ. 2026. A mechanistic evaluation of the metabolism disrupting potential of methyl tert-butyl ether. Curr Res Toxicol 10(Apr 20):100290; doi: 10.1016/j.crtox.2026.100290.

Summan M, Doepker CL, Brorby GP. 2026. Safety evaluation of an aqueous root and leaf extract of Ashwagandha (Withania somnifera). Phytother Res; doi: 10.1002/ptr.70314. Online ahead of print April 15. PMID: 41987003.

Thompson CM, Heintz MM, Rogers SI, Vincent MJ, Haws LC. 2026. Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA. Toxicol Sci April 10:kfag045; doi: 10.1093/toxsci/kfag045. Online ahead of print April 10^th. PMID: 41968070.

Bond G, Becker RA, Rish W, Ryman JP, Verwiel AH. 2026. Cumulative impact assessment within vulnerable communities: Challenges, opportunities and path forward. J Toxicol Regul Pol. Accepted, April 7, 2026.

Wikoff D, Brown L. Development of an integrated human and environmental health safety assessment framework: Initial findings and progress from a consortium effort. Abstract 1050, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Wikoff D, Fitch S, Eichenbaum G, Ejaz S, Klaren W, Southall M. Need for fit-for-purpose approaches that integrate dose, mechanism, and context of use with key characteristics when evaluating the carcinogenic potential of widely used therapeutics: A case study of acetaminophen. Abstract 4005, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Vincent M, Wheeler M, Schaefer H, Rhoden J, Fitch S, Wikoff D. Quantitative bias assessment to facilitate assessment of (un)certainty in observational data evaluating acetaminophen use and liver cancer. Abstract 4279, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Shobair M, Allen D, Ballone I, Brull M, Burbank M, Choksi N, Fitch S, Irizar A, et al. A machine-learning approach for the development of a knowledgebase to identify systemic toxicity mechanistic targets and evaluate biological space coverage. Abstract 5161, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Proctor DM, Verwiel AH, Covington TR, Thompson CM. Acute (24-hour) nickel inhalation reference concentration for use in air toxics risk assessment. Abstract 3997, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Price SA, Bare JL, Verwiel AH, Proctor DM. Novel application of the EPA All Ages Lead Model (AALM) to determine an acute (24-hour) inhalation threshold for lead protective of neurotoxicity in children. Abstract 4604, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Patlewicz G, Mihalchik A, Thompson CM, East A, Borghoff S. Investigating the feasibility of deriving a new environmentally relevant Thresholds of Toxicological Concern (TTCs) from estimated human equivalent benchmark dose (eBMD_HED) values. Abstract 4013, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Lea I, Rivera B, Rogers S, Borghoff SJ. Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence. Abstract 5206, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Klaren WD, Rivera BN, Sheppard AM, Franke K, Wikoff DS. Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety. Abstract 3653, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Klaren WD, East A, Wheeler M, Vincent M, Wikoff DS, Covington T. Probabilistic estimation of daily total nitrosamine exposures generated from drinking water and dietary nitrate and nitrate sources. Abstract 3982, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Killius A, Covell LT. Characterization of PFAS in Vermont public water systems. Abstract 3892, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Henderson RG, Hinerman J, Franzen A, Nguyen H, Wong A. Development of supplemental intake limits for nutrients. Abstract 3664, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.